Possibilities of intervention in the sars-cov-2 metabolism.

Abstract

In addition to epidemiological resources and vaccines, the virus's defenses need to be compromised in order to weaken the coronavirus pandemic. These include oxidative stress, mutations, and processing of acetyl-CoA for lipid synthesis instead of glycolysis. Antioxidants with low redox potential, selenium or iodides and fenofibrate can be used for this, which reduces the formation of malondialdehyde from lipoperoxidation. Theoretically malondialdehyde can bind to the amino group of proteins (immunoglobulins or vaccine protein) and thus protect the virus.