Glomangiopericytoma, three cases in nine days; case reports and Brief review
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Glomangiopericytoma is a rare sinonasal tumor. We report three cases of this rare disease that presented in nine days to one subspecialty practice. Histochemical and DNA sequencing confirmed the diagnosis in each case. Endoscopic sinonasal surgery provided complete resection in each case. The occurrence of three cases to one practice within a 2-week timeframe may suggest GPC is under-recognized. Routine sequencing to detect CTNNB1 mutations and staining for smooth muscle actin of suspicious sinonasal tumors may increase the frequency of GPC detection.
Citation: M. Patrick Stagg MD, Henry P.Barham MD, Rahul V. Ramaraju, Sai Samyuktha Bandaru MD, Mohamed A. Taha MD, Sanjay Juneja MD. Glomangiopericytoma, three cases in nine days; case reports and Brief review DOI: https://doi.org/10.52845/JORR/2022/3.1.1
Received: 03 October 2021; Revised: 20 November 2021; Accepted: 23 December 2021; Published Online: 04 January 2022
Copyright: ©2022 M. PATRICK STAGG MD et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Funding: None
Competing interests: None
Authorship: All authors have contributed significantly to this publication.
Corresponding author: M. Patrick Stagg MD Baton Rouge General Internal Medicine Residency Program, Baton Rouge, LA, 70809, USA
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Stout AP, Murray Mr. Hemangiopericytoma: a vascular tumor featuring Zimmermann’s pericytes. Ann surg. 1942 Jul; 116(1):26-33. Doi: 10.1097/00000658-194207000-00004.Pmid: 17858068; pmcid: pmc1543753.
Dandekar M, Mchugh JB. Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis. Arch Pathol Lab Med. 2010;p. 134–134.
Compagno J, Hyams VJ. Hemangiopericytomalike intranasal tumors. A clinicopathologic study of 23 cases. Am J Clin Pathol.1976;66(4):970369–970369.
Thompson, Lester D R, and Julie C Fanburg- Smith. “Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions.” Head and neck pathology vol. 10,1 (2016): 95-108. doi:10.1007/s12105-016-0697-6.
Kono M, Bandoh N, Matsuoka R, Goto T, Akahane T, Kato Y, et al.
Thompson LD, Fanburg-Smith JC, Wenig BM, Barnes L, Eveson JW, Reichart P, et al. Borderline and low malignant potential tumours of soft tissues. In: Pathology and Genetics of Head and Neck Tumours. IARC Press; 2005. p. 43–45.
Lasota J, Felisiak-Golabek A, Aly FZ, Wang ZF, Thompson LD, Miettinen M. Nuclear expression and gain-of-function -catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker. Mod Pathol. 2014;28(5):715–720. doi:10.1038/modpathol.2014.161.
Haller F, Bieg M, Moskalev EA, Barthelmeß S, Geddert H, Boltze C, et al. Recurrent mutations within the amino-terminal region of - catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol. 2014;185(2):563–571. doi:10.1016/j.ajpath.2014.10.019.
Thompson LD, Miettinen M, Wenig BM. Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol. 2003;27:737–749. doi:10.1097/00000478-200306000-00004.
Duval M; 2012. doi:10.1002/hed.23074.
Park Eun Su, Kim Jiyoung, Jun Sun-Young. Characteristics and prognosis of glomangiopericytoma: a systematic review. Head Neck.2017:1–13. [PubMed] [Google Scholar].
Nunnery EW, Kahn LB, Reddick RL. Hemangiopericytoma: a light microscopic and ultrastructural study. Cancer. 1981;47.
Agaimy A, Barthelmeß S, Geddert H, Boltze C, Moskalev EA, Koch M, et al. Phenotypical and molecular distinctness of sinonasal hemangiopericytoma compared to solitary fibrous tumour of the sinonasal tract. Histopathology. 2014;65(5):667–673. doi:10.1111/his.12452.
Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013;45(2):180–185. doi:10.1038/n g.2509.
Chmielecki J, Crago AM, Rosenberg M, Connor O, Walker R, Ambrogio SR, et al. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet. 2013;45(2):131–132. doi:10.1038
/ng.2522.
Mosquera JM, Sboner A, Zhang L, Chen CL, Sung YS, Chen HW, et al. Novel MIR143- NOTCH fusions in benign and malignant glomus tumors. Genes Chromosomes Cancer. 2013;52(11):1075–1087. doi:10.1002/gcc.22102.
Dandekar M, Mchugh JB. Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis. Arch Pathol Lab Med. 2010;p. 134–134.
