Recurrent Parotitis in Monozygotic Twins with Pseudohypoaldosteronism and IgA Deficiency

Abstract

Juvenile recurrent parotitis (JRP) is the second most common inflammatory salivary gland disease of childhood and is characterized by recurring episodes of painful parotid swelling that often co-occur with symptoms of fever and malaise. The etiology and pathogenesis of JRP remains elusive, but various predisposing factors likely contribute to disease development including congenital ductal malformations, hereditary genetic factors, infection, immunodeficiency, and autoimmune disease. We present a unique case of monozygotic 21- month-old male twins with histories of IgA deficiency and pseudohypoaldosteronism both presenting with recurrent same-sided parotitis. Both twins underwent simultaneous parotid duct dilation with steroid irrigation and resulted in favorable outcomes. Although this condition is self-limiting after adolescence in more than 90% of cases, a prompt diagnosis and effective treatment can drastically improve the quality of life of affected children [42].